Triboelectric nanogenerator (TENG) that converts mechanical energy into electricity has been considered as an economical strategy for energy harvesting. In this study, we present a promising strategy to simultaneously enhance the performance and stability of cellulose acetate-based TENG by employing N,N-dimethylformamide (DMF) treatment. The amide functional groups can strongly interact with cellulose acetate and form desirable surface dipole, thereby improving the output performance of C-TENG. Remarkable output characteristics with open-circuit voltage (V_(oc)) of 348V and short-circuit current (I_(sc)) of 16μA are attained with DMF solvent treatment. Importantly, this strategy can also be applicable to smart textiles, which can light up 46 light-emitting diodes through human motion. More encouragingly, the resulting TENG also exhibits excellent durability, affording nearly unchanged V_(oc) over 180,000 operation cycles. Our results are very promising to accelerate the development of self-powered wearable integrated microsystems based on environmental-friendly TENG technology.