癌症剋星，精準醫療科技：THOR-BNCT於臺灣發展的現況與前景

Cancer Conqueror, Precision Medical Technology: Current Status and Future Prospects of THOR-BNCT Development in Taiwan

劉珈均(Jia-Jun Liu) ； 陳之碩(Chi-Shuo Chen) ； 蔣孟伶(Meng-Ling Chiang) ； 劉鴻鳴(Hong-Ming Liu)

《科儀新知》 236期 (2023/09) Pp. 74-87

摘要

硼中子捕獲治療運用硼中子捕獲反應以直接摧毀腫瘤細胞，減少周遭正常組織傷害。在這個過程中，提高硼藥物遞送效率通常是影響硼中子捕獲治療成效的關鍵因素之一；確保中子源產生高品質的中子束也是實現癌症治療目標的重要一環。目前，臺灣使用 THOR-BNCT反應器來生成超熱中子束，這在臨床治療與研究領域已取得顯著進展，BNCT除了為腦瘤以及復發性頭頸癌患者提供新的治療希望之外，更有機會擴大適應症範圍，以提供病患有效的治療選擇。

並列摘要

Boron neutron capture therapy (BNCT) is a treatment that uses the boron neutron capture reaction to target and destroy tumor cells while minimizing damage to surrounding healthy tissue. The efficient delivery of boron drugs and the quality of neutron beams are both critical components in determining the effectiveness of BNCT. In Taiwan, the THOR-BNCT reactor is utilized to generate epithermal neutron beams, which have demonstrated significant contributions to clinical treatment and research fields. BNCT has already achieved successful results in treating patients with brain tumors and recurrent head and neck cancer, and its potential to treat a wide range of indications is expected to benefit more patients in the near future.