器官晶片技術與應用－以肺晶片為例

Organ-on-a-chip Technology and Application-Taking Lung-on-a-chip as an Example

陳冠宇(Guan-Yu Chen) ； 石昂東(Ang-Tung Shih) ； 李珊宣(Shan-Hsuan Li)

《科儀新知》 239期 (2024/06) Pp. 22-32

摘要

長久以來，實驗動物在新藥開發中扮演著重要角色，然而越來越多研究顯示，動物實驗結果與人體臨床試驗之間存在巨大差異，在研發上需更有效的試驗方法，預測藥物在人體內的功效及安全性，其中器官晶片（organ-on-a-chip, OoC）技術能準確模擬體內複雜結構、細胞生理等優勢，提供更精準且可靠的實驗結果，加速臨床前藥物研發過程，近年已受到國際上極大關注，本文將依序介紹OoC的研發背景、核心技術，並以肺晶片（lung-on-a-chip, LoC）為例說明相關應用實例。

並列摘要

For a long time, animal testing has played a crucial role in the development of new drugs. However, an increasing number of studies have shown significant differences between the results of animal experiments and human clinical trials, highlighting the need for more effective testing methods to predict the efficacy and safety of drugs in humans. Among these, organ-on-a-chip (OoC) technology, with its ability to accurately simulate complex bodily structures and cell physiology, offers more precise and reliable experimental outcomes, thereby accelerating the preclinical drug development process. This technology has garnered immense international attention in recent years. This article will sequentially introduce the background of OoC research, its core technologies, and present the lung-on-a-chip (LoC) as an example to illustrate related application instances.