摘要
掌蹠紅斑觸痛徵候群亦稱爲手足症候群，乃在使用某些類的化學藥物治療時，出現之一種特別但普遍的皮膚毒性反性，其中以pegylated liposomal doxorubicin(PLD)最多，發生的機轉尚不了解。處置掌蹠紅斑觸痛徵候群主靠藥物減量和延長用藥間隔時間。其它尚可使用局部濕潤藥膏、著寬鬆衣物、避免接觸尖端物體和減少負重的活動，使用維他命B6(pyridoxine)，前列腺素、類固醇和dimethyl sulfoxide藥膏等。
並列摘要
Palmar-plantar erythrodysesthesia (PPE) is a distinctive and relatively frequent dermatologic toxic reaction associated with certain chemotherapeutic agent. PPE represents the most common manifestation of pegylated liposomal doxorubicin (PLD) skin toxicity and is the agent's most frequent dose limiting side effect. The pathophysiology of PPE, as it occurs with any drug with which it is associated, is not well understood. Management of PPE requires careful monitoring and prompt response with either dose reduction or treatment delay. Use of moisturizing creams, loose clothing, and avoidance of sharp objects or heavy activity are helpful conservative measures. Several studies have suggested that pyridoxine, corticosteroid, prostaglandins or dimethyl sulfoxide may ameliorate and accelerate resolution of PLD-induced PPE.