Central poststroke paresthesia is characterized by a persistent abnormal sensation in the body after a cerebrovascular accident. Between 1998 and 2001, 89 stroke patients admitted to the Chia-Yi Christian Hospital were diagnosed as having central poststroke paresthesia. Fifty-two of them, 25 ales and 27 females with a mean age of 58 years, participated in the two-phase study. During phase one, patients were observed without any specific treatment for the paresthesia. Forty-four patients then entered phase two and received amitriptyline therapy. Fourteen patients (31.8%) reported alleviation of the paresthesia. Our data indicated that amitriptyline might be useful in the management of central poststroke paresthesia.