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以玻璃體內注射Triamcinolone Acetonide (Kenacort-A)治療非動脈炎性前缺血性視神經病變的成效－病例報告
Intravitreal Injection of Triamcinolone Acetonide for Treatment of Nonarteritic Anterior Ischemic Optic Neuropathy-A Case Report
摘要
目的：報告一例患有兩側非動脈炎性前缺血性視神經病變(Nonarteritic anterior ischemic neuropathy(NAION))的七十歲男性，接受玻璃體內注射Kenacort-A的治療成效。 方法：在玻璃體內注射4 mg/0.1 ml Kenacort-A到右眼，而左眼並未接受任何治療。 結果：接受玻璃體內注射Kenacort-A的右眼，其視力和視野都有明顯的改善，而沒有接受治療的左眼，其視力和視野皆進一步的惡化。 討論：在玻璃體內注射Kenacort-A，形成局部高壓濃度的類固醇，而降低因缺血所造成的視神經盤水腫，且更進一步地抑制因視神經腫大所造成的視神經盤水腫，且更進一步地抑制固視神經血液循環不足的惡化。但此治療成效，仍需要更廣泛的臨床病例才能加以證實。
關鍵字
無資料並列摘要
Purpose: To report a case of bilateral nonarteritic anterior ischemic optic neuropathy (NAION) and evaluate the effect of intravitreal triamcinolone acetonide injection on the treatment of NAION. Method: Intravitreal injection of 4 mg Kenacort-A was performed in one eye with NAION. The fellow eye did not receive any treatment. Visual acuity, visual field, and color fundus photography were performed in both eyes. Results: Disc edema was partially resolved and improvement in visual function was noted 4 days after intravitreal injection of Kenacort-A in the right eye. Both visual field and visual acuity furthere deteriorated in the fellow untreated eye. Conclusions: Intravitreal injection of triamcinolone acetonide might eliminate disc swelling and terminate the vicious cycle of scleral outlet compartment syndrome in NAION. Randomized clinical trials of a larger sample are necessary to confirm the effect of the treatment.