- 期刊
Injected Haloperidol-Induced Motor Deficits are Potentiated in Rats Drinking Green Tea as a Sole Source of Water: Relationship with Dopamine Metabolism in the Caudate
以綠茶為大鼠唯一飲水來源可能與Haloperidol誘發運動障礙有關：與多巴胺代謝關係
摘要
The antipsychotic drug ”haloperidol” (HAL) has been widely used for the treatment of a range of neuropsychiatric disorders. However treatment also induces extrapyramidal symptoms (EPS) including short term parkinsonism and late complication tardive dyskinesia (TD). These idiopathic symptoms are associated with serious limitations in this therapy. Some studies have suggested that oxidative stress induced during the metabolism of HAL is involved in the elicitation of EPS. We speculated if green tea may prevent HAL-induced EPS because of its antioxidant properties. In the present study, the efficacy of green tea extract (GTE) given as a sole source of water on HAL-induced EPS male albino wistar rats was examined. We found that HAL-induced motor deficits and elicitation of TD were more severe in GTE than water dinking animals. HAL-induced dopamine level was increased and its metabolites concentrations were higher in the nucleus accumbens and lower (p ＜ 0.01) in the caudate of GTE-drinking than water-drinking animals. Increased ratios of homovanillic acid (HVA) and 3, 4-dihydroxyphenylacetic acid (DOPAC)/dopamine in the caudate may be involved in the precipitation of HAL-elicited EPS while drinking GTE. Conversely GTE increased the level of dopamine moreover raised its metabolites in the nucleus accumbens may relapsed the schizophrenic symptoms while on the treatment HAL. We thus suggest that patients on HAL therapy should avoid green tea.
關鍵字
綠茶 ； Camellia sinensis ； Haloperidol ； Nucleus Accumbens ； Caudate Putamen ； 錐體外症候群 ； 帕金森氏症 ； 遲發性不自主運動症候群 ； 遲發性肌躍症並列摘要
The antipsychotic drug ”haloperidol” (HAL) has been widely used for the treatment of a range of neuropsychiatric disorders. However treatment also induces extrapyramidal symptoms (EPS) including short term parkinsonism and late complication tardive dyskinesia (TD). These idiopathic symptoms are associated with serious limitations in this therapy. Some studies have suggested that oxidative stress induced during the metabolism of HAL is involved in the elicitation of EPS. We speculated if green tea may prevent HAL-induced EPS because of its antioxidant properties. In the present study, the efficacy of green tea extract (GTE) given as a sole source of water on HAL-induced EPS male albino wistar rats was examined. We found that HAL-induced motor deficits and elicitation of TD were more severe in GTE than water dinking animals. HAL-induced dopamine level was increased and its metabolites concentrations were higher in the nucleus accumbens and lower (p ＜ 0.01) in the caudate of GTE-drinking than water-drinking animals. Increased ratios of homovanillic acid (HVA) and 3, 4-dihydroxyphenylacetic acid (DOPAC)/dopamine in the caudate may be involved in the precipitation of HAL-elicited EPS while drinking GTE. Conversely GTE increased the level of dopamine moreover raised its metabolites in the nucleus accumbens may relapsed the schizophrenic symptoms while on the treatment HAL. We thus suggest that patients on HAL therapy should avoid green tea.