A solitary sternal uptake is critical for prognosis in patients with breast cancer. We describe a case of breast cancer involving synchondrosis sternalis presented as a solitary uptake mimicking physiological uptake. A 54-year-old woman with a history of left breast cancer and chest pain 1 year ago was referred for screening of metastatic disease. Tc-99m MDP bone scan revealed a heterogeneous uptake around synchondrosis sternalis mimicking a physiological uptake. The magnified view favored a metastatic lesion based on lytic and blastic uptake pattern combined with a history of breast cancer. A subsequent biochemical, physical examinations and chest CT depicted it as a solitary osteolytic sterna metastasis.