摘要
背景：血清中的尿酸是抗氧化作用的物質，也是代謝指標。脂肪肝已知是肝臟脂肪氧化不良的結果，所以我們認為尿酸上升，應是脂肪肝的臨床診斷指標之一。 方法與對象：我們回顧96年，本院承接員工體格檢查的所有接受腹部超音波檢查，排除B型、C型肝炎以及經常性的飲酒習慣者。針對所有相關的危險因子，加以分析，其中我們對於尿酸的值特別獨立分析。我們將血清中尿酸濃度分成高低四分位，再分析不同分位的脂肪肝盛行率。 結果：總數有6996位受檢者，男性有4641位受檢者(66.3%)。血清尿酸值四分位是25%分位為5mg/dl，50%分位是6mg/dl，75%分位是7 mg/dl。我們以第一級四分位為參考值，第二級四分位的脂肪肝發生危險率為1.64倍，第三級四分位則為2.87倍，第四級則為4.776倍。以多變數邏輯性迴歸分析卻發現身體質量數分組也是有差異，但在不同的身體質量數分組下，尿酸與脂肪肝的盛行率也呈現正相關。 結論：我們認為尿酸本身有抗氧化作用，但更是身體代謝的指標，可以做為身體的氧化還原包括脂肪肝的指標之一。
並列摘要
Background: serum uric acid is a potent antioxidant and an index of metabolic rate. We knew fatty liver formation is due to lipid poor oxidation in the liver. So we suppose high uric acid will be an important index to fatty liver. Materials and Methods: We retrospectively the year of 2006, those received abdominal ultrasonography, except hepatitis B, hepatitis C and consumption of alcohol. According the possible risk factors, we analyzed as previous survey do, but we focus on the influence of the uric acid. We use the method to classified the serum uric acid into quartiles, then surveys the prevalence of fatty liver. Results: Totally 6996 persons was recruited in this survey. Male are 4641 66.3%). Serum uric acid 25% quartile is 5 mg/dl，50% quartile is 6 mg/dl，75% quartile 7 mg/dl. We use the first quartile as reference data. The second quartile relative risk is 1.64, the third quartile is 2.87 and the fourth is 4.776. We use the multiple variable regression, in different body mass index and sex, uric acid quartile also play a good indictor to predict the prevalence of fatty liver. Conclusion: Although uric acid is a potent antioxidant, it is a good metabolic and oxidative damage indicator. That is a good indictor for fatty liver in the clinical situiation.