Vacuum-assisted closure (VAC) therapy not only retains wounds moisture but also accelerates cells and vessels grow, which facilitates granulation tissue and wound healing. To report a case of diabetic foot ulcer patient who had been treated for three years is hospitalized again due to severe wound infection. However, because of the poor effect by traditional wet dressing therapy following the debridement surgery, we changed to adopt VAC treatment and discussed further therapeutic effect. The caring period is during 2021/09/14-2021/10/01. Hope the experience will afford the references to nurses who take care of the patients with diabetic foot ulcer in the future.