Amphetamine is a potent central nervous system stimulant and a substance of widespread abuse. There are fewer cases of amphetamine-induced myocardial infarction to guide therapy, and there are no care guidelines. The initial electrocardiography (ECG) may be unreliable in the setting of methamphetamine-related acute coronary syndrome (ACS), with false-positive ST-segment elevation prompting unneeded thrombolytic therapy. This case reminds us that we should manage the patient who has a low risk for coronary artery disease but takes drugs like Amphetamines and presents with typical symptoms of ACS.