The pulmonary manifestations of cryptococcosis are diverse but most commonly include single or multiple pulmonary nodules and segmental or lobar consolidation. A large mass-like pattern is an uncommon finding. We report a case of 47-year-old healthy male presenting with a large pulmonary cryptococcoma with poor response to medical treatment alone. The patient was satisfactorily treated with a left pneumonectomy under cover of fluconazole therapy. Thus, thoracic surgery may be indicated in the event of a failure of medical therapy, and pulmonary cryptococcosis should be considered in the differential diagnosis of a mass lesion. Literature concerning the diagnosis and management of pulmonary cryptococcosis is also reviewed.