- 期刊
Lupus Erythematosus (LE) Cells in Pleural Effusion: Initial Diagnosis of Systemic Lupus Erythematosus by Cytological Examination-Two Case Reports and Review of the Literature
肋膜液中發現LE細胞：藉由細胞學檢查診斷系統性紅斑性狼瘡－病例報告與文獻回顧
摘要
系統性紅斑性狼瘡是自體免疫疾病，可影響許多器官。多樣性的表現會混淆我們的目光，特別是初到院時只有少量的証據存在。漿膜炎也常在系統性紅斑性狼瘡病人身上表現。困難處在於如何在一個沒有診斷而且年紀大的男病人身上得到一些蛛絲馬跡，引導我們向免疫疾病的方向追查。在體液中發現LE細胞，也許是一個不錯的線索。 我們報告兩位年紀大的男病人，一開始以肋膜炎為最初表現。在男性老年族群中，系統性紅斑性狼瘡是比較少見的。在他們的肋膜積液中，我們藉由常規的細胞學檢查，意外發現LE細胞的存在。病人血清中也呈現高濃度的的ANA及anti-ds DNA，從而確立了系統性紅斑性狼瘡的診斷。這兩位病人接受類固醇治療後，症狀得到不錯的改善。我們回顧有關LE的文獻，並提出體浚細胞學檢查不僅是偵測惡性細胞的常規檢查，對於良性的疾病，如系統性紅斑性狼瘡也扮演一定的角色。
並列摘要
Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organs. The diverse manifestations can be confusing and may obscure the diagnosis, especially when few clues are present at the beginning. Serositis is 1 of the various presentations, and the presence of LE (lupus erythematosus) cells in the body fluid may be a hint leading to the final diagnosis of SLE. Herein, we present 2 male patients diagnosed with SLE with an initial presentation of pleuritis. Although SLE is unusual in this population, the finding of LE cells in the pleural effusion prompted an immunologic survey. The diagnosis of SLE was confirmed with the high titer of ANA and antids ANA. The literature regarding LE cells is reviewed, and we conclude that cytologic examination of the body fluid is not only a useful tool for detecting malignant cells, but also has a role in detecting benign diseases, such as SLE.