Pulmonary adenofibroma is a rare primary benign mesenchymal lung tumor that has been seldom reported in the currently available literature. Unusual lung tumors constitute a broad range of histological types that unsurprisingly have a wide spectrum of imaging appearances and clinical presentations. Herein, we report a 60-year-old male who complained of low-grade fever and general malaise, and was tentatively diagnosed as having acute hepatitis and pleural effusion, accompanied with the incidental finding of pulmonary nodule on chest computed tomography (CT), which was ultimately diagnosed as pulmonary adenofibroma. The initially challenging frozen section reading raised the suspicion of malignancy, but ultimately the diagnosis was revised to benign pulmonary adenofibroma. This case can increase our awareness of this extremely rare benign lesion in the future.