Tuberculosis (TB) usually involves the lungs, which is the site of about 90% of mycobacterial infection. TB of the chest wall is a rare entity. Herein, we reported 2 cases of TB of the chest wall presenting as an abscess without intrapulmonary involvement. Computerized tomography of the thorax showed anterior chest wall abscess without evidence of underlying lung or pleural disease. Sputum examination revealed negative acid-fast bacilli in the smear and TB culture. Both patients were diagnosed by surgical pathology and tissue culture, and were treated with complete resection combined with anti-tuberculous therapy.