Peribronchiolar Metaplasia - Interstitial Lung Disease: Case Report and Review of the Literature

Chen-Chieh Lin ； Mong-Wei Lin ； Kuei-Pin Chung ； Yih-Leong Chang

《胸腔醫學》 38卷2期 (2023/06) Pp. 136-141

摘要

Peribronchiolar metaplasia (PBM) is a histological change that features the extension of bronchiolar-type epithelial cells along the alveolar walls adjacent to the bronchioles. The exact mechanisms leading to PBM are not well understood, and may be related to non-specific reactions to tissue injury. Peribronchiolar metaplasia - interstitial lung disease (PBM-ILD) is rarely reported in the literature, and is considered as a subtype of ILD with bronchiolocentric patterns. While focal PBM commonly appears in various chronic ILDs, diffuse PBM in the lungs is the principal pathological hallmark of PBM-ILD. Here, we reported a case of PBM-ILD that may have been caused by long-term incense smoke exposure. Our report indicates that surgical biopsy is crucial for diagnosis of ILD with unusual clinical and radiological presentation.

關鍵字

interstitial lung disease ； peribronchiolar metaplasia ； bronchiolocentric pattern ； incense smoke exposure