Amiodarone is a widely-used antiarrhythmic agent. One of the most serious and well-discussed adverse effects of amiodarone is pulmonary toxicity, which can lead to severe pulmonary fibrosis if not diagnosed and managed promptly. Here, we reported a patient with multiple pulmonary nodules over bilateral lower lungs, which was initially suspected to be malignancy. The lung biopsy confirmed the diagnosis of amiodarone pulmonary toxicity. The lung nodules were resolved after amiodarone discontinuation and corticosteroid treatment.