Miliary Tuberculosis and Identification of Tuberculosis-Immune Reconstitution Inflammatory Syndrome (TB-IRIS)-A Case Report

Chia-Ju Wu ； Yen-Han Tseng ； Sheng-Wei Pan ； Jia-Yih Feng ； Yuh-Min Chen

《胸腔醫學》 39卷4期 (2024/12) Pp. 319-326

摘要

Miliary tuberculosis (TB), an often-fatal infectious disease in the absence of intervention, is increasingly observed among immunocompromised individuals. This case study presented a middle-aged man with rheumatoid arthritis who developed miliary TB following anti-tumor necrosis factor-alpha antibody therapy. Sputum conversion was achieved 3 months after the initiation of therapy, but the patient subsequently experienced TB-immune reconstitution inflammatory syndrome characterized by multi-organ involvement.

關鍵字

miliary tuberculosis ； tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) ； immunocompromised ； rheumatoid arthritis ； disease-modifying anti-rheumatic agents (DMARDs) ； anti-TNF-α antibody