- 期刊
組織間挿植熱治療使用熱透導管系統之研究
Study of Interstitial Hyperthermia Using a Thermofuse System
摘要
目的：以組織挿植方式，籍一次於腫瘤的針管挿植，可精確且足夠地給予放射治療及熱治療(hyperthermia)兩種相輔相成的治療，提高局部治療率。以電磁波或射頻(radiofrequency)為熱源，加溫及測溫易受其物理性之干擾。本研究之目的乃在於研究以熱透式導管(thermofuse)熱治療儀使用組織挿植溫度分佈的情形。 材料與方法：使用熱透導管熱治療儀，分別於熱治療之假體，豬肉及活體豬，依三至五層面(plane), 以積體式(voiume)式挿植針管，每層面五根，每根依10,12, 15mm 間距共三組。以熱偶(thermocouple)實測挿植區內、外不同位置溫度之分佈及變化情形，分析並相互比較。 結果：於假體、豬肉與活體豬皆可藉調整循環前之水溫，使10及12 mm間距之挿植區內達到理想之治療有效溫度，於活體豬內15mm部份間距，挿值區內則未達熱治療理想的溫度。活體豬內測溫顯示近血管區域，溫度顯著下降1.4~2.0℃。 結論：本研究顯示，使用熱透導管系統作組織間挿植熱治療，能於腫瘤區域藉針管之挿植及不受物理性因素條件干擾之測量，精確地給予及實測有效治療溫度, 其加熱與測溫之準確性為目前其他體外熱治療，所無法比擬。估計與放射治療合用可提昇療效，對存活期長之實質瘤(solid tumor)，助益尤多。
並列摘要
Purpose: Using intersitial implantation, one needle implantation procedure provides for two complimentary treatment modalities of radiotherapy and hyperthermia with adequate dose and temperature distribution, subsequently improving the local control. Problems of interference of heat delivery and temperature measurement exist when we use microwave or radiofrequency as the heating source, This study aims at investigating the heat distribution using interstitial thermofuse system. Material and Methods: Thermofuse hyperthermia system was used to study on phantom, pork and alive pigs. Volume needle implantation with 3-5 planes, 5 needles per plane were implanted. They were devided into 3 groups with 10, 12 and 15mm needle spacing. Thermocouples were used to measure the temperature distribution inside and outside implantation areas. The data were analyzed and compared. Results: In the study of phantom, pork and alive pigs, the implantation volume could achieve ideal and effective hyperthermia temperatures at 10, 12 mm spacing through the adjustment of water temperature before circulation. In alive pigs, with a 15 mm needle spacing, the implanted volume could not achieve ideal temperatures. The temperatures were significantly decreased by 1.4-2.0℃in the areas near the vessels. Conclusion: This study shows that interstitial hyperthermia using thermofuse system is able to precisely provide effective hyperthermia temperature without the interference of physics parameters in thermo-measurement in implanted tumor areas. The accuracy of heat delivery and temperature measurement is better than other external hyperthermia systems. We estimate that the combination with radiotherapy can improve the treatment effect of solid tumors. It is expected more beneficial, especially for those solid tumors with relatively long survivals.