- 期刊
成人軟組織肉瘤病人之術後輔助性放射治療
Postoperative Adjuvant Radiotherapy for Adult Patients with Soft Tissue Sarcoma
摘要
背景：本研究之目的在分析成人軟組織肉瘤之病人在新光醫院接受術後輔助性放射治療之存活情形。 材料與方法：從1993到1996共有的16位成年病患在新光醫院，因軟組織肉瘤接受手術後輔助性放射治療，其中男性7人女性9人。臨床TNM分期係依照醫院之病歷紀錄，11位病患在治療後接受定期門診追蹤，5位病患在接受定期門診追蹤一段時間後，最後以電話追蹤合併全國死亡登記來確認存活情形。其因病存活率(OS=overall cause specific survival)，局部無復發存活率(LRRF8=local regional relapse free survival)，遠端無轉移存活率(MFS=distant metastasis free survival)，無病存活率(DFS=disease free survival)係依Kaplan-Meier方法計算。 結果：在追?7-81個月後(中位數：55)，一位病人死於局部復發，兩位病人死於遠端肺轉移，一位病人死於其他疾病(肝癌)，其餘病人無復發情形。三年及五年因病存活率(OS)分別為87.5％及80％。三年及五年局部無病發存活率(LRRFS)均為92.3％。三年及五年遠端無轉移存活率(DMFS)均為84%。三年及五年無病存活率(DFS)均為77%。併發症共兩例：直腸出血一例(RTOG第三級)，傷口癒合不良一例(RTOG第四級)。 結論：依本院之經驗，成人軟組織肉瘤病人手術後放射治療可接致高度局部控制，而併發症並不常見。
關鍵字
成年軟組織肉瘤,手術後放射治療並列摘要
Background: The aim of this study is to analyze the survival status of adult patients with soft tissue sarcoma who received postoperative adjuvant radiotherapy at Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. Materials and Methods: From 1993 through 1996, 16 adult patients (M: 7, F: 9) were diagnosed with soft tissue sarcoma (STS) to be treated with postoperative adjuvant radiotherapy in our institute. TNM staging was based on the hospital medical records. The survival status was based on regular follow-up (11/16) and interrupted follow-up combined with national mortality registry and telephone visits (5/16). The overall cause specific survival (OS), local-regional relapse free survival (LRRFS), and distant metastasis free survival (DMFS), and disease free survival (DFS) were analyzed using the Kaplan-Meier method. Results: After a median follow-up of 55 (7-81) months, 12 patients are survivors without disease, one died of local relapse, two died of distant metastases, and one died of concurrent disease (HCC). The OS, LRRFS, DMFS, and DFS at 3 years and 5 years were 87.5% and 80%, 92.3% and 92.3%, 84% and 84%, and 77% and 77% respectively. The complications included one rectal bleeding (RTOG grade III) and one poor wound healing (RTOG grade IV). Conclusion: In our experience, postoperative adjuvant radiotherapy can achieve high local controlled rate in adult soft tissue sarcoma with acceptable complication.