- 期刊
高滲葡萄糖注射用於骨關節炎
Hypertonic Dextrose Injections for Osteoarthritis
摘要
人口結構老齡化，伴隨著某些好發於老年人的疾病其盛行率的提高，骨關節炎正是此類疾病之一，骨關節炎不但會使病人因疼痛感到不適，更會因關節活動受限而影響病人的日常生活功能。目前對於骨關節炎的臨床治療指引內容包括非藥物、藥物、手術等大類，主要著眼於緩解症狀以及減輕關節殘疾影響，通常要求病人先從調整自身習慣等非藥物方法開始，如仍無法控制病程始予藥物治療或手術處置。在關節注射刺激性溶液的治療方式往往被稱為增生療法（prolotherapy），屬於非手術治療方式之一，該法最常使用的是高滲葡萄糖溶液，因其容易取得且成本較低。由於此法尚非目前主流治療方式，本文彙整高滲葡萄糖溶液用於骨關節炎的統合分析或系統回顧結果的較新進展，就其治療效果與潛在風險進行探討，對於病人如不適用或不接受目前主流治療時，醫病都可以有多一個臨床選擇的參考。
並列摘要
Among the elderly, an increase in the prevalence of certain diseases, such as osteoarthritis, has been observed. Patients with osteoarthritis not only experience discomfort and pain but also have limited range of motion in the joints, which lowers their quality of life. At present, non-drug, drug, and surgical treatment options are available for patients with osteoarthritis; these approaches mainly focus on relieving symptoms and reducing the impact of joint disability. Initially, non-drug therapies, such as those focusing on changing the habits of patients, are usually administered. If the disease remains uncontrolled following non-drug therapy, drugs are administered and/or surgery is considered. The treatment comprising injecting irritant solutions into joints is known as prolotherapy, which is a non-surgical treatment method. In this method, the most commonly used irritant solution is hypertonic glucose because it can be obtained easily at a low cost. Since prolotherapy is not yet considered a mainstream treatment, herein, we have summarized the outcomes of recent meta-analyses or systematic reviews on the application of hypertonic glucose solution for osteoarthritis treatment and discussed its therapeutic effects and potential risks. For patients who are not suitable for or refuse to receive mainstream treatments, prolotherapy could be a promising treatment choice.