Withdrawal behavior is defined as increasing the distance between themselves and the organization of psychological and physiological, this situation has a great impact on the overall effectiveness of the organization. The purpose of this study is to explore the relationship between workplace friendship, well-being and withdrawal behavior. Data were collected from 186 full-time Hong Kong workers at three time-points. The results found that workplace friendship has a negative effect on withdrawal behavior. Workplace friendship has a positive effect on well-being. Well-being has a negative effect on withdrawal behavior. Moreover, well-being mediates the relationship between workplace friendship and withdrawal behavior.