Due to the improvement of medical technique, the value of Percutaneous Transluminal Coronary Angioplasty (PTCA) has been widely appreciated. The number of patients receiving this treatment has increased greatly and the nature of the disease treated by PTCA has also become more complicated. It is important to advance the knowledge and nursing care intervention of PTCA. The purposes of this article were to introduce the process. PTCA, the aspects in technique of hemostats, position and time in bed, timing of activated clotting time level and removal of the sheath. Nursing interventions in promoting patient comfort maintenance of peripheral tissue perfusion, prevention of complications and maintenance of adequate cardiac output after PTCA; discharge education, including wound care, medication exercise risk factors, signs of occlusion and the importance of follow up were also discussed. This article provided a guideline for post-PTCA care, which was useful for both healthcare providers and patients.