並列摘要
Crohn's disease is chronic inflammatory disease of unknown etiology that affects any portion of the gastrointestinal tract. The choice of drug is depend on the location of disease, the severity of disease, and the goal of therapy. Anti-inflammatory drugs, antibiotics, and oral glucocorticoid can be treated in patients with mild to moderate disease. For moderate to severe disease, immunomodulators or biologic agents can be used. Consider to use combination therapy with immunomodulators and biologic agents if the severity of disease is exacerbation. The long-term efficacy and side effects of combination therapy still be evaluated in large-scale clinical trial.