透明細胞瘤(clear cell syringoma)為一罕見之汗管瘤變異型。本文報告一位58歲女性,自青春期起於兩側眼眶周圍呈現許多無症狀、1-3 mm大小之膚色小丘疹。病理切片下顯示淺部真皮層中有數個由透明細胞包圍著汗管所形成的腫瘤小葉。病患母親及女兒自青春期後也有類似皮膚病灶。病人有糖尿病病史四年,並以口服降血醣藥物控制。吾人回顧相關文獻,並討論透明細胞汗管瘤與糖尿病之關係。
Clear cell syringoma is a rare variant of syringoma. We report a 58-year-old woman who has had numerous asymptomatic, 1 to 3 mm, skin-colored papules over the bilateral periorbital areas since puberty. The histopathological examination showed several small lobules of clear cells with centrally located eccrine ducts in the upper dermis. Her mother and daughter had the same lesions since puberty. The patient was diagnosed as having diabetes mellitus in 1995 and was treated with oral anti-hyperglycemic agents. The related literature is reviewed and we discuss the association between clear cell syringoma and diabetes mellitus.