播散性Bacille Calmette-Guérin感染

Disseminated Bacille Calmette-Guérin Infection

陳柏菁(Bo-Jing Chen) ； 蘇維鈞(Wei-Juin Su) ； 劉明真(Ming-Tzen Liu) ； 陳長齡(Chang-Lin Chen) ； 王鑄軍(Chu-Kwan Wong)

《中華皮膚科醫學雜誌》 19卷3期 (2001/09) Pp. 255-260

摘要

Bacille Calmette-Guerin(BCG)疫苗用來預防肺結核，此疫苗之安全性極高。但是在免疫缺損之病患仍然可能造成嚴重感染。吾人報告一例患有嚴重混合免疫不全疾病之男嬰接種BCG疫苗之後發生播散性感染。皮膚病理切片顯示有許多抗酸性桿菌存在，且PCR分析證實皮膚、腦脊髓液與胃液抽取物之菌種均為Mycobacterium bovis。雖然給予抗結核菌藥物之治療與骨髓移植，病患仍不治死亡。

並列摘要

Bacille Calmette-Guerin(BCG) vaccine is administered to prevent tuberculosis and is considered to have an excellent safety profile. However, severe BCG infection can occur in individuals with defects of the host immune response. We report an eight-month-old male baby suffered from severe combined immunodeficiency with disseminated BCG infection. Skin biopsy showed numerous acid-fast bacilli and PCR analysis of skin, cerebral spinal fluid and gastric aspirate all identified Mycobacterium bovis. Patient died despite anti-TB drugs and bone marrow transplantation.

並列關鍵字

BCG infection ； Severe combined immunodeficiency