Livedoid Vasculopathy -Report of One Case Treated with Warfarin-

青斑樣血管病變─以Warfarin治療之病例報告─

黃逸明(Yi-Ming Huang) ； 胡俊弘(Chun-Hong Hu) ； 李婉若(Woan-Ruoh Lee)

《中華皮膚科醫學雜誌》 20卷1期 (2002/03) Pp. 51-56

摘要

青斑樣血管病變是一種慢性疾病，臨床上以足部、踝部與腿部反覆出現疼痛性潰瘍而癒合後留下萎縮性疤痕為特徵，組織學上則以血管內有纖維素沉澱為特徵。我們報告一個42歲男性，一年半來因在兩側下肢患有反覆發作的多發性之深部結痂潰瘍。對於傳統的治療包括dipyridamole、pentoxyphylline、與aspirin的反應皆非常差。Warfarin是一種口服的抗凝血劑，我們投以每日3.75mg至今約有兩個月。經Warfarin治療後即無新皮膚病變發生，原先之皮膚病變也得到明顯的改善。

並列摘要

Livedoid vasculopathy is a chronic disorder characterized clinically by recurrent painful ulcers of the feet, ankles and legs that heal with residual white atrophic scars and histologically by intravascular deposition of fibrin. We report a 42-year-old man who has had recurrent multiple painful, deep-crusted ulcerations with erythematous bases over bilateral lower legs for one and a half years. Therapeutic response to dipyridamole, pentoxyphylline and aspirin was very poor. Oral anticoagulant, warfarin was administered at 3.75mg/day and maintained for 2 months. New lesions have not recurred and existing lesions have improved after 2 months.

並列關鍵字

Livedoid vasculopathy ； Warfarin