- 期刊
Acrodermatitis Continua of Hallopeau -A Case with Lesions Localized at Bilateral Thumbs Successfully Treated with Dapsone-
Hallopeau連續性肢端皮膚炎－病灶侷限於兩側拇指並成功以Dapsone治療之病例－
摘要
一位六十六歲男性，兩年多來於雙手拇指罹患有連續性肢端皮膚炎具痛感之膿疱疹， 並伴隨有指甲失養以及明顯的手部功能喪失。施以局部類固醇軟膏，煤焦油和calcipotriol軟 膏皆無法改善其肢端病灶，因而開始以dapsone每日200mg治療。肢端病灶在療程第二週就 有顯著改善。於是嘗試將dapsone減至每日150mg，但卻隨即有新的膿疱出現。將dapsone 劑量增加回每日200mg後，肢端病灶再度獲得明顯改善。在六週的治療期間內並無與dap- sone相關的副作用產生。停藥後個月追蹤並無復發跡象，而新指甲也開始長出。
關鍵字
無資料並列摘要
A 66-year-old male suffered from painful pustular eruptions of acrodermatitis continua of Hallopeau on bilateral thumbs for about 2 years, with associated nail dystrophy and markedly disabled manual skills. Initial treatment with topical corticosteroids, tars and calcipotriol failed to improve the acral lesions. Dapsone therapy began at a dose of 200 mg/day, which cleared the acral lesions within two weeks of therapy. However, new lesions relapsed when the dose was tapered to 150 mg/day. Increasing dapsone back to 200 mg/day was followed by another clearance of the acral pustules. During a total course of 6-week therapy, no dapsone-related side effects were noted. The patient remained symptom-free and nail growth was noted at the follow-up visit 3 months after the medica- tions were discontinued.