- 期刊
以Tazarotene加上凡士林和calcipotriol用於治療板塊乾癬左右兩側之比較
Right-Left Study Comparing of Tazarotene-Petrolatum with Calcipotriol in Chronic Plaque Psoriasis
摘要
有許多研究證實tazarotene對乾癬有療效，但是用在台灣人身上的效果尚無正式報告。本研究的目的是比較每天使用一次tazarotene凝膠及一次凡士林和每天使用兩次的calcipotriol油膏對於治療乾癬的效果、副作用以及有效緩解的間期。自2002年3月至2002年10月，我們收集共計23位患者（21位男性和2位女性），50對對稱患部接受治療。患者年齡分布從12到80歲不等，平均年齡為60.2歲。試驗過程包括12週的治療期以及停藥後4週的觀察期。到第12週治療結束時，兩者對於脫屑、板塊突起、泛紅及整體嚴重度的改善同樣有效。然而在第16週（即停藥4週時）觀察結果，tazarotene加上凡士林比calcipotriol有更好的維持效果。
關鍵字
無資料並列摘要
In the treatment of plaque psoriasis, tazarotene was known to be effective, but its efficacy in a Taiwanese population has not been reported. Our purpose was to compare the efficacy, side effects and the duration of therapeutic effects of a once - daily tazarotene 0.1 % gel plus petrolatum with the standard twice daily calcipotriol 0.005% ointment in the treatment of patients with plaque psoriasis. A total of 23 Taiwanese patients (21 male and 2 female) with 50 pairs of psoriatic lesions were recruited from March 2002 to October 2002. The patients were aged from 12 to 80 years with a mean age 60.2 ± 7.3. The study consisted of a session of 12-week treatment and an interval of observation 4 weeks after treatment. At the end of the treatment (week 12), tazarotene-petrolatum was as effective as calcipotriol in the reduction of scaling, plaque elevation, erythema and overall severity. However, tazarotene-petrolatum demonstrated a better maintenance effect than calcipotriol after cessation of therapy at week 16.