Human Papillomavirus - Associated Bowen's Diseases of the Neck

人類乳突病毒相關的頸部多發性波文氏病

蔡宗樺(Tsung-Hua Tsai) ； 吳育弘(Yu-Hung Wu) ； 孫培倫(Pei-Lun Sun) ； 蘇信義(Hsin-Yi Su) ； 曾嶔元(Chin-Yuan Tzen) ； 陳秀琴(Hsiu-Chin Chen)

《中華皮膚科醫學雜誌》 22卷1期 (2004/03) Pp. 29-34

https://doi.org/10.29784/DS.200403.0002

摘要

人類乳突病毒已知與肛門會陰部的癌症生成有關，也曾被報告出現在其它皮膚的波文氏病，其位置最常在手上面，且都是黏膜型的人類乳突病毒。我們報告一例七十三歲女性，在後頸部發生與人類乳突病毒相關的多發性波文氏病。將病灶利用連鎖聚合酶反應和脫氧核糖核酸序列分析發現人類乳突病毒第十六型。雖然檢查並沒有發現人類乳突病毒引起的肛門會陰部病灶，仍建議她需要接受定期的追蹤檢查。人類乳突病毒第十六型是高危險性黏膜型的乳突病毒，已知是子宮頸癌和會陰部的波文氏病和波文樣丘疹病的致病因子，在本病例後頸部出現與此病毒相關的波文氏病，表示與人類乳突病毒相關的波文氏病並非只侷限在會陰部。

並列摘要

Human papillomavirus (HPV) is known to be involved in the pathogenesis of anogenital cancer. However, it has also been demonstrated in some patients with extragenital Bowen's disease, mainly on the hands, and it usually involves a mucosal type of HPV. We report a 73-year-old woman who had multiple Bowen's disease lesions on the nape of her neck. HPV - 16 DNA was detected in the lesions by means of PCR and DNA sequence analysis. No anogenital lesions related to HPV infection were present. Periodic examination was recommended. HPV type 16, a high risk mucosal type HPV, has been established as a causative agent of cervical neoplasia, bowenoid papulosis and Bowen's disease in the genital region. HPV - 16 DNA is associated with Bowen' disease in this case, suggesting that HPV - related Bowen's disease is not always restricted to the genitalia.

並列關鍵字

Extragenital Bowen's disease ； Human papillomavirus ； Polymerase chain reaction