- 期刊
角質層下膿疱性皮膚病－病例報告
Subcorneal Pustular Dermatosis: A Case Report
摘要
角質層下膿疱性皮膚病（Subcorneal pustular dermatosis，以下簡稱SPD），是一種罕見的皮膚疾病，主要在軀幹和四肢會反覆發生膿疱的慢性皮膚病，病理特色是皮膚角質層下方的嗜中性球聚集，然而其致病機轉仍不明。我們報告一72歲男性，病人過去被視為乾癬，曾接受過光照、口服A酸與局部類固醇藥物治療，但均無法有效控制病情。理學檢查皮膚表現呈多發性紅斑或形成環型排列並伴隨小膿疱的發生，主要分布於胸腹部與四肢，皮膚病理切片顯示角質層下之膿疱內含以嗜中性球為主之浸潤，而免疫螢光檢查和血清學檢查都無異常發現，病人對dapsone治療有極佳的反應，病灶在治療後三週幾乎完全消失，僅留下皮膚色素沉著。我們報告台灣首例的角質層下膿疱性皮膚病(SPD)病例。
關鍵字
無資料並列摘要
Subcorneal pustular dermatosis (SPD) is a rare skin disorder characterized by a chronically relapsing vesicopustular eruptions affecting the trunk and extremities. The pathogenesis of SPD remains obscure despite the fact that it is characterized by subcorneal accumulation of neutrophils. We reported a 72-year-old male patient who was previously treated as psoriasis with phototherapy, neotigason, and topical steroids; however, all these treatments were ineffective in controlling the disease. On examination, the skin manifestations revealed multiple erythematous annular or serpiginous patches studded with tiny pustules over the trunk, groins and extremities. The histopathology disclosed subcorneal pustules infiltrated by neutrophils, and the immunofluorescent studies showed negative findings. Furthermore, the patient responded well to dapsone treatment in 3 weeks. We suggest this is the first documented case of SPD in Taiwan.