摘要
顆粒性角化不全是一種少見、良性的、長在對磨部位的皮疹，表現出特殊的臨床病理變化。臨床上，顆粒性角化不全表現為癢、過度角化、有裂縫的斑塊在發紅的皮膚上，影響皮摺的部位。病理下可以看到在緊密、過度角化不良的角質層有許多嗜鹼性透明角質顆粒。我們報告兩個顆粒性角化不全的病例，第一個病例在胯下和腋下注射肉毒桿菌素後，病灶迅速和完全的消失。五個月後，病人仍未復發。第二個病例是四歲男孩，在兩側腹股溝有典型的病灶並和外用製劑的使用可能有關。
關鍵字
無資料並列摘要
Granular parakeratosis (GP) is an uncommon, benign cutaneous eruption of intertriginous areas that represents a distinctive clinicopathologic entity. Clinically, GP presents with variably pruritic, hyperkeratotic, fissured papules and plaques over an erythematous base, affecting the cutaneous folds. Histological examination shows a characteristic picture with presence of abundant basophilic kerato-hyaline granules within a compact, hyperparakeratotic stratum corneum. We describe two cases of granular parakeratosis. In case one, the lesions cleared rapidly and completely after botulinum toxin injections to the axillae and groins. At 5-months' follow-up, the patient remained asymptomatic. Case two is a 4-year-old boy with characteristic lesions in the groins associated with topical agents used.