- 期刊
Elevated Serum Tissue Polypeptide Antigen in a Patient with Mycosis Fungoides
發生於一位皮膚T細胞淋巴瘤病人血液中的組織多胜抗原升高現象
摘要
組織多胜抗原(TPA)在不同固體腫瘤（包括肺癌、乳癌、和膀胱癌）病人血液中會升高，可是這項腫瘤標記和血液腫瘤的關連很少被報導過。我們在此報告一位皮膚T細胞淋巴瘤病人，臨床表現為全身性鱗屑化，臀部與大腿泛紅，雙邊鼠蹊淋巴結腫大，與周邊血液發現有異常的淋巴球。在一系列的腫瘤標記測驗結果中只有組織多胜抗原升高，比正常值的最高值高3倍。詢問病史，身體檢查，血液檢驗與各種放射核醫攝影在這病人身上並沒有找到其他腫瘤。經過兩次的化學治療後，此病人的皮膚症狀已獲改善，而且TPA已降回正常值。因此我們希望組織多胜抗原對某些皮膚T細胞淋巴瘤病人能有臨床上的參考價值。
關鍵字
無資料並列摘要
Tissue polypeptide antigen (TPA) is a tumor marker which has been found to be elevated in various solid tumors, including cancers of the lung, breast, and bladder. However, there have been very limited reports regarding the association of this tumor marker with hematologic malignancies. We here report a patient with mycosis fungoides (MF), presenting with generalized scaling involving ＞90% of the total body surface area, erythema of buttocks and thighs, bilateral inguinal lymphadenopathy, and atypical lymphocytes found in the peripheral blood. A series of tumor markers were found to be within normal limits except TPA, which was elevated three times above the upper normal limit. The presence of another primary tumor was excluded by history taking, physical examination, blood tests, and various radiological and nuclear imaging. Following two courses of chemotherapy, the patient's skin condition improved, and her serum TPA level returned to normal. These findings suggest that serum TPA may prove to be clinically significant in a subset of patients with mycosis fungoides.