Acquisition of the oral microflora begins at birth and the first bacteria found in the oral cavity are derived from the mother. Following teeth eruption, the oral cavity became a more complicated environment and established a unique ecological niche for the oral bacteria. Periodontitis is considered as infectious in nature. The presence of putative pathogens especially certain gram negative anaerobic bacteria may increase the risk of developing periodontitis. There are conflicting opinions as to whether periodontal pathogens are exogenous or endogenous inhabitants in the oral cavity. New technology provides the tools to have the chance to distinguish the subspecies groups and can further evaluate the possibility of transmission of the periodontal pathogens. This review discusses the evidence of the possible transmission routes between spouse, parents to child and among children, and the possibility of periodontitis as a contagious disease.