- 期刊
Porphyromonas gingivalis釋放gingipain在牙周疾病所扮演的角色
Role of Gingipain of Porphyromonas gingivalis in Periodontal Disease
摘要
Porphyromonas gingivalis是一個重要的牙周致病菌，對牙周組織的破壞威力非常強大，其釋放的enzyme-gingipain扮演重要之角色。Gingipain是一個typsin-like enzyme，對許多cytokine或它們的receptor都有分解的作用，造成免疫抑制的反應，它也會對人類的凝血機制產生影響，甚至造成結締組織的崩解、加深牙周組織的破壞，以從中獲得養分。以下內文是針對gingipain產生致病作用的機制，闡述其在牙周疾病中所扮演的角色。
並列摘要
Porphyromonas gingivalis (Pg) is a crucial periodontal pathogen which can destroy the periodontal tissue significantly. The enzyme, gingipain released by Pg, has a great contribution in this effort. Gingipain is a typsin-like enzyme. It can degrade various cytokines or the receptors over immune cells to cause immune suppression. Gingipain can also have influences on blood clotting system; moreover, it will cause connective tissue deconstruction and extensively damage the periodontal tissue. This article is a systemic review of the pathogenic mechanism of gingipain and the role of gingipain in periodontal disease.