According to the literature, the article is to review and discuss the influence of smoking to the periodontal disease. This article first proposed harmful matter of tobacco to human body and the application methods of tobacco. Afterwards, from the viewpoint of microbiology and immunology to discuss smoking that may be a possible pathogenesis factor to periodontal disease, as well as the influence of clinical outcome of different kinds of periodontal treatment. All of these needs further research to support.