External apical root resorption is one of the common sequela following orthodontic treatment. The incidence of reported root resorption during orthodontic treatment varies widely because of the great variation in the patient selection, measurement method, time differentials and tooth movement mechanism. Numerous studies have been conducted, attempting to establish the factors causing root resorption among the orthodontic patients. Recent clinical and laboratory investigations find the degree and severity of external apical resorption during orthodontic tooth movement is multifactorial. Caution should be exercised in orthodontic patients with tooth trauma history or having abnormal shaped roots, in whom the clinicians plans to large displacement of the anterior teeth, or in patients who have been in the active treatment for a longer than usual period of time, especially for the adult patients. These high risk patients should be fully informed before the orthodontic treatment. Periodic follow-up with perioapical radiographs for the patients is strongly recommended.