c-Fos在軟、硬組織中表現之探討

Expression of c-Fos in Soft and Hard Tissue

梁世怡(Shih-Yi Liang) ； 劉哲宇(Che-Yu Liu) ； 龔素芳(Sue-Fang Kung) ； 何坤炎(Kuen-Yen Ho) ； 傳鍔(Earl Fu) ； 謝耀東(Yao-Dung Hsieh)

《臺灣牙周病醫學會雜誌》 14卷1期 (2009/03) Pp. 63-78

https://doi.org/10.6121/TAP.200903_14(1).0007

摘要

c-Fos是一個轉錄因子，研究發現它在發炎反應、細胞分化、細胞成熟、腫瘤形成與細胞凋亡中都有參予，且與另一轉錄因子NF-κB作用途徑相關。目前已知NF-κB在發炎途徑上扮演的重要角色已經被許多實驗研究證明，然而c-Fos在發炎反應尤其是牙周炎性疾病中的作用定位未明。因此本文將針對c-Fos的家族及特性、活化因子、在慢性發炎反應過程中扮演的角色，與在牙周組織中對骨骼、結締與表皮組織的影響和牙周疾病之相關聯性做一文獻回顧的探討。

關鍵字

牙周病 ； c-Fos ； 發炎

並列摘要

c-Fos is a transcription factor which is involved in the inflammation reaction, cell differentiation, cell maturation, oncogenesis and apoptosis process. It also correlated with the functioning process of another transcription factor NF-κB. The role of NF-κB plays in inflammation process was well studies by many researches. Nevertheless, The role of c-Fos plays in inflammation process especially periodontitis is uncertain. The present article will briefly review the c-Fos family and their character, activation factors and function in chronic inflammation as well as their impact on bone, connective tissue and the correlation with periodontal disease.

並列關鍵字

periodontal disease ； c-Fos ； inflammation