Branemark developed a novel dental implant system in 1965 and highlighted the concept of osseointegration. He published a case report with ten-year follow-up in 1977. In the last five decades, dental implant therapy has become one of the more optimal solutions when replacing missing teeth in partially and fully edentulous patients. Although several studies have reported over 90% implant survival rates, peri-implant disease sometimes occurs and this presents a challenge to clinicians. To date, there is lack of scientific evidence regarding predictable treatment options for peri-implant disease. This article aims to review the definition and prevalence of peri-implant mucositis and explores related treatment options.