Drug-induced Gingival Overgrowth: Report of Two cases

藥物性牙齦增生：案例報告

Jia-Xuan Hu(胡家瑄) ； Szu-Han Wang(王思翰) ； Po-Chun Chang(張博鈞) ； Mark Yen-Ping Kuo(郭彥彬)

《臺灣牙周病醫學會雜誌》 27卷2期 (2022/12) Pp. 188-201

https://doi.org/10.6121/TAP.202212_27(2).0006

摘要

Gingival overgrowth (GO) is clinically manifested by generalized and fibrotic enlargement of the gingiva. It often impairs the oral hygiene maintenance and esthetics. The most recognized GO is drug-induced gingival overgrowth (DIGO) which is a side effect of the administration of three groups of medicaments: anticonvulsants (phenytoin), calcium channel blockers (nifedipine, amlodipine), and immunosuppressant (cyclosporine A). This case report describes two patients with marked GO who had been medicated with phenytoin or amlodipine. After finishing nonsurgical managements including oral hygiene instructions, scaling and root planing, surgical treatment including gingivectomy and periodontal flap management under local anesthesia was performed to remove excess GO tissues that may accompanied by osseous defect in these two cases. No recurrence was noted after 15 months and 24 months of surgery, respectively. These results showed DIGO can be treated with non-surgical or surgical periodontal treatment without adjusting patient's medicaments.

關鍵字

amlodipine ； gingival overgrowth ； phenytoin

並列摘要

牙齦增生在臨床上會表現出廣泛性牙齦纖維化肥大的現象，通常會影響口腔衛生的維持以及美觀，其中最常見的為抗癲癇藥物、免疫抑制劑以及鈣離子阻斷劑等藥物引起的藥物性牙齦增生。本篇案例報告介紹了兩位分別服用抗癲癇藥物苯妥英及鈣離子阻斷劑氨氯地平並具有明顯牙齦增生的病人，在經過口腔衛生指導、牙結石清除等非手術治療後，藉由牙齦切除術及翻瓣手術移除多餘的牙齦增生組織以及伴隨之骨缺損，在分別追蹤15個月及24個月後沒有復發的現象。顯示藥物性牙齦增生可藉由牙周非手術及手術治療而不需調整病人的藥物。

並列關鍵字

牙齦增生 ； 苯妥英 ； 氨氯地平