- 期刊
局部使用氯己定（Chlorhexidine）於牙周疾病與植體周圍炎之效果
Effect of Locally Delivered Chlorhexidine in The Treatment of Periodontitis and Peri-Implantitis
摘要
葡萄糖酸氯己定〈氯己定；Chlorhexidine gluconate；CHX〉是一種廣效型的抗菌藥物，它對於各種類的微生物，包括細菌、酵母菌和病毒都擁有有效的殺菌能力，分子帶有正電荷，而大多數細菌以及口腔內的構造表面、包含牙齒表面以及黏膜則帶有負電荷，在異極相吸的結果之下，CHX能夠很強的鍵結到以上這些結構的表面上。而使用上必須注意其副作用像是味覺改變、牙齦上牙結石的過度形成、軟組織的過敏反應以及軟組織和牙齒的染色。近年來，CHX在牙齦炎與牙周疾病中的治療被廣泛有效的使用並研究。我們統整目前常見CHX在牙周疾病局部使用的劑型有以下幾種不同的類型，如：漱口水、可降解之薄片、凝膠態產品、牙膏產品和氯己定漆。而本文將藉由文獻回顧，來探討經由各種途徑局部使用CHX於牙周及植體周圍疾病之效果。
並列摘要
Chlorhexidine gluconate (CHX) is a broad-spectrum antiseptic that can be antimicrobial, bactericidal, and bacteriostatic depending on dose and species. CHX is a cationic agent of the bisbiguanide class and acts to strongly bind with negatively-charged sites on cell walls, which destabilize cell walls, and disrupts osmosis. It is well known for its substantivity due to the ability to bind with carboxyl groups of the mucin that covers the oral mucous and maintain a potent sustained release. However, attention must be paid to possible side effects of CHX such as changes in taste, excessive deposition of supra-gingival calculus, allergic reactions to soft tissues, and staining of soft tissues and teeth. In recent years, CHX has been widely used and studied in the treatment of gingivitis and periodontal disease. The most common mediums used to deliver CHX includes mouthwash, bio-degradable chips, bioadhesive gels, dentifrice products, and CHX varnish. In this study, we will investigate the effects of locally delivered CHX in periodontal and peri-implant diseases through the different vehicles mentioned above.