富含血小板纖維蛋白於牙周組織再生與齒槽骨保存術之應用：文獻回顧

The Use of Platelet-Rich Fibrin in Periodontal Regeneration and Alveolar Ridge Preservation

林信宏(Hsin-Hung Lin) ； 徐世勳(Shih-Shiun Shyu) ； 邱賢忠(Hsien-Chung Chiu)

《臺灣牙周病醫學會雜誌》 24卷2期 (2019/12) Pp. 102-110

https://doi.org/10.6121/TAP.201912_242.0004

摘要

富含血小板纖維蛋白（platelet-rich fibrin, PRF）是血液離心後的產物，因為製做簡單而且富含豐富的生長因子，因此在牙周傷口癒合中提供了許多幫助，能增進血管新生，刺激幹細胞生長分化，吸引並促進骨細胞再生。臨床上應用富含血小板纖維蛋白於自然牙周圍能促進軟、硬組織早期癒合，得到完整牙周再生。應用於拔牙後的齒槽骨保存則可獲得較快的軟組織癒合，幫助減少骨吸收量。透過本文獻回顧討論富含血小板纖維蛋白應用在牙周組織再生及齒槽骨保存術之成效，讓臨床醫師對此有更多認識與了解，並在臨床生物材料上能多一選擇與考量。

關鍵字

富含血小板纖維蛋白 ； 牙周組織再生 ； 齒槽骨保存術

並列摘要

Platelet-rich fibrin (PRF) is made from centrifugation of blood. It provides lots of growth factors which aid in angiogenesis and proliferation and differentiation of stem cells and progenitor cells, playing a crucial role in the wound healing process. Thus, PRF can be used in periodontal defects by accelerating the healing of soft and hard tissue to gain the regeneration of the periodontium. As for extraction sockets, the application of PRF can reduce the post-operation discomfort and promote the soft tissue healing, helping to reduce the bone resorption resulting from the tooth removal. This review of studies investigating the cell biology of PRF and its application in periodontal regeneration and ridge preservation is able to provide clinicians in clinical practice with additional options and considerations.

並列關鍵字

platelet-rich fibrin ； periodontal regeneration ； ridge preservation