- 期刊
引導骨再生術生物材料的選擇：文獻回顧
Selections of Biomaterials and Clinical Efficacy of Guided Bone Regeneration: A Literature Review
摘要
塌陷的無牙脊區域進行植牙重建時可能需於植牙手術前或手術同時施行脊豐隆術，引導骨再生術為脊豐隆術的一種術式，其原理是以再生膜阻隔生長較快的上皮細胞及結締組織纖維母細胞，以助於生長較慢的骨先驅細胞形成骨頭。引導骨再生術常合併放置移植骨，幫助維持空間及提供生物機制以利於新骨生成，自體移植骨被認為是移植骨的黃金標準，但仍有供給部位不適與有限的移植骨供給等缺點，因此臨床上常以其它移植骨取代。臨床上有許多不同的生物材料，需了解其優缺點以運用於不同病例，本文介紹不同再生膜及移植骨的特性，並回顧隨機對照試驗研究，比較不同再生膜及移植骨效果的差異，提供臨床治療時的思考策略。
並列摘要
Ridge augmentation before or during implant reconstruction may be a necessary procedure in atrophic edentulous areas. Guided bone regeneration is one of ridge augmentation techniques. The principle of guided bone regeneration is based on the use of a barrier membrane to exclude rapidly proliferating epithelial cells and connective tissue fibroblasts thus promoting the growth of slower-growing osteoprogenitor cells. Guided bone regeneration is usually combined with bone grafts, which are used to maintain the space and provide biological mechanisms for bone regeneration. Autogenous bone is considered as the ''gold standard" material; however, the main concerns are donor site morbidity and limited available amount. Therefore, the substitution with other types of bone graft is the alternative choice. Clinically, we need to understand the properties, advantages and disadvantages of variety biomaterials to apply to each individual case. Therefore, the aim of the present article was to introduce the properties and assess the clinical efficacy of various membranes and bone grafts through review randomized controlled trials, to provide the strategic thinking when treating patients.