Have library access?
  • Journals


Parkinson's Disease Treatment and New Drugs Development



Parallel abstracts

Parkinson's disease (PD) is a common neurodegenerative disease. Clinical symptoms of PD include motor symptoms of bradykinesia, rigidity, rest tremor, and various non-motor symptoms. To date, there is no cure for PD, but we have many medications for symptomatic relieve and improvement of patients' quality of life. The medications for PD include levodopa, dopamine agonist, monoamine oxidase B inhibitor, and cate-O-methyltransferase inhibitor. In early-stage PD, treatment focuses on improving quality of life and prevention or delaying the development of motor complication by adjusting medications to mimic the physiological continuous dopaminergic stimulation in brain. In advanced stage of PD, treatment focuses on how to decrease daily "off" time, increase "on" time and improve dyskinesia. The first part of this article will describe the medications for PD and treatment concept. The second part of this article will describe the three new drugs for PD in Taiwan and other new PD medications outside Taiwan.


Abbott A. Levodopa: the story so far. Nature 2010;466:S6-7. https://doi.org/10.1038/466S6a
Olanow CW, Calabresi P, Obeso JA. Continuous dopaminergic stimulation as a treatment for Parkinson's disease: Current status and future opportunities. Mov Disord 2020;35:1731-44. https://doi.org/10.1002/mds.28215
Cilia R, Akpalu A, Sarfo FS, et al. The modern pre-levodopa era of Parkinson's disease: insights into motor complications from sub-Saharan Africa. Brain 2014;137(Pt 10):2731-42. https://doi.org/10.1093/brain/awu195
Olanow CW, Rascol O, Hauser R, et al. A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N Engl J Med 2009;361:1268-78. https://doi.org/10.1056/NEJMoa0809335
Rascol O, Hauser RA, Stocchi F, et al. Long-term effects of rasagiline and the natural history of treated Parkinson's disease. Mov Disord 2016;31:1489-96. https://doi.org/10.1002/mds.26724