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Deep Brain Stimulation for Parkinson's Disease



Parallel abstracts

In the early stage of Parkinson's disease (PD), it mainly relies on dopamine-related drugs for treatment, but when the course of the disease enters the middle and late stage, patients often experience severe fluctuations in drug efficacy and various drug complications, causing major sufferings in Parkinson's disease patients and their families. Deep brain stimulation therapy (DBS) is a brand-new treatment method born under the plight of drug treatment. DBS therapy delivers electrical current into certain brain regions to regulate abnormal nerve signals in the motor circuit. In addition to treat the motor symptoms of PD movement disorders, DBS also improves the fluctuation of drug effects, reduces the patient's dependence on drugs, and ameliorates the occurrence of dyskinesia, which greatly improves the efficacy of treatment and quality of life in PD patients. Our country's National Health Insurance has also started to pay for DBS treatment of PD since 2015, so today this treatment has become a standard treatment option for PD patients in Taiwan. The whole process of DBS treatment is very complicated, from the screening of patients, through the operation process, to the operation of the pulse generator after surgery, which requires a team with sufficient ability and experience to proceed this process smoothly. This article will take you through various aspects of deep brain stimulation treatment for Parkinson's disease, including DBS mechanism, the timing of treatment, indications and contraindications, surgical techniques, treatment effects and potential side effects, as well as important DBS trends in future development, to help everyone understand this epoch-making new therapy for PD.


Benabid AL, Pollak P, Gao D, et al. Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg 1996;84:203-14. https://doi.org/10.3171/jns.1996.84.2.0203
Bergman H, Wichmann T, DeLong MR. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science 1990;249:1436-8. https://doi.org/10.1126/science.2402638
Benazzouz A, Gross C, Féger J, et al. Reversal of rigidity and improvement in motor performance by subthalamic high‐frequency stimulation in MPTP‐treated monkeys. Eur J Neurosci 1993;5:382-9. https://doi.org/10.1111/j.1460-9568.1993.tb00505.x
Brown P, Williams D. Basal ganglia local field potential activity: Character and functional significance in the human. Clin Neurophysiol 2005;116:2510-9. https://doi.org/10.1016/j.clinph.2005.05.009
Bove F, Mulas D, Cavallieri F, et al. Long-term outcomes (15 Years) after subthalamic nucleus deep brain stimulation in patients with Parkinson disease. Neurology 2021;10.1212. https://doi.org/10.1212/WNL.0000000000012246