- 期刊
Low-dose Aspirin does not Increase Pregnancy Rates and Uterine Artery Blood Flow Velocity in Male-factor Infertility Patients Undergoing Intracytoplasmic Sperm Injection
服用低劑量阿司匹靈對於因男性不孕症接受單精蟲顯微授精的婦女不會增加其懷孕率及子宮血流
摘要
Objective: To determine the effects of low-dose aspirin on uterine artery blood flow velocity and pregnancy rate in an unselected group of patients undergoing intracytoplasmic sperm injection (ICSI). Material(s) and Method(s): A total of 126 ICSI procedures were analyzed prospectively. Inclusion criteria allowed only first-trial couples with long-standing infertility caused by a male factor. Besides the exclusion of female factors, the patient population was unselected. The aspirin (+) (n = 66) group received 80 mg aspirin beginning on the first day of the gonadotropin stimulation, and the aspirin (-) (n = 60) group received no treatment. Result(s): Duration of stimulation, serum levels of estradiol on the hCG day; total medication dosage of gonadotropin; numbers of mature oocytes collected; numbers of embryos transferred, were not significantly different. Clinical pregnancy rates were 25.0% versus 26.5% in aspirin treated and untreated groups (P＞ 0.05). Uterine artery pulsatility index (P1) and resistant index (RI) values on the hCG day were 2.30±0.50 and 0.80±0.05 in aspirin treated group versus 2.20±0.48 and 0.80±0.11 in aspirin untreated group, respectively (P＞ 0.05). Conclusion(s): Low-dose aspirin (80 mg) appears to have no beneficial effect on uterine blood flow velocity and pregnancy rates in an unselected group of patients undergoing ICSI for male factors infertility.
並列摘要
Objective: To determine the effects of low-dose aspirin on uterine artery blood flow velocity and pregnancy rate in an unselected group of patients undergoing intracytoplasmic sperm injection (ICSI). Material(s) and Method(s): A total of 126 ICSI procedures were analyzed prospectively. Inclusion criteria allowed only first-trial couples with long-standing infertility caused by a male factor. Besides the exclusion of female factors, the patient population was unselected. The aspirin (+) (n = 66) group received 80 mg aspirin beginning on the first day of the gonadotropin stimulation, and the aspirin (-) (n = 60) group received no treatment. Result(s): Duration of stimulation, serum levels of estradiol on the hCG day; total medication dosage of gonadotropin; numbers of mature oocytes collected; numbers of embryos transferred, were not significantly different. Clinical pregnancy rates were 25.0% versus 26.5% in aspirin treated and untreated groups (P＞ 0.05). Uterine artery pulsatility index (P1) and resistant index (RI) values on the hCG day were 2.30±0.50 and 0.80±0.05 in aspirin treated group versus 2.20±0.48 and 0.80±0.11 in aspirin untreated group, respectively (P＞ 0.05). Conclusion(s): Low-dose aspirin (80 mg) appears to have no beneficial effect on uterine blood flow velocity and pregnancy rates in an unselected group of patients undergoing ICSI for male factors infertility.