- 期刊
Advanced Endodermal Sinus Tumor with Contralateral Dermoid Tumor during Pregnancy: A Case Report and Literature Review
並列摘要
Objective: An endodermal sinus turner (EST) of the ovary and a contralateral dermoid cyst occur rarely in pregnancy. Alternative treatment for reducing the long-term sequelae in both the mother and fetus should be considered during pregnancy. Case Report: At 27 weeks of gestation, a patient was diagnosed with advanced EST, FIGO (International Federation of Gyneeology and Obstetrics) stage ilie, by magnetic resonanee imaging and surgery. Following optimal debulking surgery, three cycles of multi-agent chemotherapy, consisting of 2S mg/m2 cisplatin and 100 mg/m2 etoposide on days 1 to 4, were instituted at 21-day intervals. Maternai seru m a-fetoprotein and CA 125 titers soon returned to normal pregnancy leveis. A healthy male infant was delivered at 38 weeks of gestation by cesarean section, after which a second-Iook laparotomy was performed. The micropathologic findings were negative for malignancy, except that a dermoid tumor of the right ovary was confirmed. Consolidation treatment with two cycles of chemotherapy, consisting of’20 mg/m2 cisplatin and 100 mgjm2 etoposide on days 1 to S and a total of 30 mg! day of bleomycin on days 6 and 7, was administered at 28day intervals. The patient had no evidence of disease for 16 months, and her infant son has shown adequate Conclusions: For pregnant women with an EST of the ovary, the optimal treatment modalities might be initial optimal debulking surgery followed by alternative chemotherapy, and further standard chemotherapy after delivery. [Taiwanese J Obstet Gynecol 2004;43(2): 113-119]