- 期刊
胎盤素化妝品抗老化功效的評估研究
Evaluation of the Anti-aging Effectiveness of Placenta Extract-containing Cosmetic
摘要
隨者年齡增長，皮膚的膠原纖維中的膠原蛋白及彈性蛋白減少，玻尿酸含量降低，使得真皮層的組織失去柔軟性與彈性，結果導致皺紋形成、萎縮、乾燥和不規則色素化現象。化妝品配方中所使用的胎盤素一般認為可能含有維生素、胺基酸、生長因子等成分，故市場中含胎盤素護膚產品常宣稱可以減少細紋，並且防止皮膚過度角質化與老化。然而，截至目前為止，並未有科學研究指出胎盤素對皮膚保養的可靠證據。本研究設計含胎盤素的安定乳霜配方，將胎盤素添加入化妝品配方中，自製乳霜黏度為2250cps，屬於不油膩延展性乳霜體。經過安定性與安全性貼布試驗後，再利用多功能皮膚測定系統評估此乳霜之抗老化功效。研究結果顯示，十三位健康皮膚受試者（30～60 歲女性）每日兩次塗抹乳霜於全臉皮膚，每週測測量皮膚彈力參數並計算其變化率，結果顯示含胎盤素乳霜能有效增進皮膚彈性。大部分受試者在使用乳霜後，彈力參數R2, R5與R7之數據提高，而彈力參數R6則明顯下降。本研究顯示含胎盤素乳霜有效增進臉部皮膚彈性。後續研究將探討胎盤素抗老化之可能作用機轉。
並列摘要
With increasing age, the skin undergoes degenerative changes include loss of elasticity, degeneration of elastic fiber, reduction in collagen and hyaluronic acid content, ultimately leading to increased wrinkling, atrophy, dryness and irregular pigmentation. The possible component of placenta extract includes vitamins, amino acid and growth factors. Commercial placenta extract-containing skin care products were claimed to decrease fine wrinkles of skin, prevention of skin over-keratinization and aging. However, there is no science report about the evidence-based skin care effects of placenta extract. A stable cream containing porcine placenta extract was prepared and its viscosity was 2250cps, which mean that cream is an un-oily external cream. After stabilization test and skin patch test, the potential anti-aging efficacy of the designed cream evaluated by multiple-function skin determine system. Thirteen female volunteers (age 30~60) applied the test cream to face twice daily, the skin elastic parameters R2, R5 and R7 were increased and the parameter R6 was decreased weekly. Our preliminary results indicated that the placenta-content cream improves the face skin elasticity. Further study will be performed to elucidate the possible anti-aging mechanism of placenta extract.