A 42-year-old male was admitted with intermittent fever and abdominal fullness. Abdominal ultrasonography and computed tomography (CT) showed dilatation of common bile duct (CBD), common hepatic duct (CHD) and intrahepatic duct (IHD). Supple stones were also noted. Duodenoscopy revealed a dilated papillary orifice with mucin discharge. Endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic cholangiograpy (PTC) showed dilatation of the CBD and left IHD. Movable filling defects were found within the dilated CBD and IHD. All these findings were compatible with mucinous secreting tumor in biliary tract. The patient received left lobectomy of the liver, choledocholithotomy with T-tube drainage and cholecystectomy. During operation a colonic mass over the ascending colon near the hepatic flexure area was incidentally found. Right hemicolectomy was performed. Pathological diagnosis were papillomatosis of IHD with secondary biliary cirrhosis and adenocarcinoma of colon.