- 期刊
Elevated Interleukin-10 Levels Correlate with Disease Activity in Systemic Lupus Erythematosus
全身性紅斑性狼瘡介白質-10之升高和其疾病活動度呈相關性
摘要
Background: We analyzed the relationship between serum interleukin (IL)-10 levels and disease activity in patients with systemic lupus erythematosus (SLE). Methods: The study enrolled 50 SLE patients and 30 healthy adults who were used as the control group. The IL-lO levels in the serum were determined and compared according to disease activities, which were measured using the SLE Disease Activity Index (SLEDAI) and laboratory parameters such as C3, C4, anti-dsDNA antibodies, IgG, IgM and IgA. Results: The IL-IO levels of the SLE patients were significantly higher than those of the control group (34.3 ± 7.2 vs 5.8 ± 1.2 pg/ml, p ＜ 0.05). Serum IL-l0 titers in SLE patients positively correlated with the SLEDAI (r = 0.42, P ＜ 0.01) and anti-dsDNA antibodies (r = 0.3, P ＜ 0.05), but negatively correlated with complement C3 levels (r = -0.45, p ＜ 0.01). However, there was no significant association between IL-l0 and C4 levels. Conclusions: Our study demonstrated that serum levels of IL-10 were elevated in SLE patients and increased lL-10 correlated with SLE disease activity.
並列摘要
Background: We analyzed the relationship between serum interleukin (IL)-10 levels and disease activity in patients with systemic lupus erythematosus (SLE). Methods: The study enrolled 50 SLE patients and 30 healthy adults who were used as the control group. The IL-lO levels in the serum were determined and compared according to disease activities, which were measured using the SLE Disease Activity Index (SLEDAI) and laboratory parameters such as C3, C4, anti-dsDNA antibodies, IgG, IgM and IgA. Results: The IL-IO levels of the SLE patients were significantly higher than those of the control group (34.3 ± 7.2 vs 5.8 ± 1.2 pg/ml, p ＜ 0.05). Serum IL-l0 titers in SLE patients positively correlated with the SLEDAI (r = 0.42, P ＜ 0.01) and anti-dsDNA antibodies (r = 0.3, P ＜ 0.05), but negatively correlated with complement C3 levels (r = -0.45, p ＜ 0.01). However, there was no significant association between IL-l0 and C4 levels. Conclusions: Our study demonstrated that serum levels of IL-10 were elevated in SLE patients and increased lL-10 correlated with SLE disease activity.